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More importantly, the human studies that now exist directly contradict the animal findings

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Common Side Effects Research suggests that enclomiphene is generally well tolerated, with a lower rate of side effects compared to clomiphene[15][11]

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However, in hypertensive patients, endothelial function is often compromised, leading to what is known as endothelial dysfunction. Typically, these cells modulate blood vessel dilation and contraction by releasing factors like NO, prostaglandins, and endothelin, thereby stabilizing blood pressure