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Homocysteine is formed when SAMe, an important methyl donor, gives its methyl group to one of the following enzymes: GAMT to make creatine PEMT to make phospholipids COMT to metabolize estrogen HNMT to eliminate histamine PNMT to make epinephrine/adrenalin ASMT to make melatonin Because of this methyl group donation, SAMe becomes SAH

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