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- Dosage: 100 mcg to 300 mcg, taken 2-3 times daily

(contd.) ---------------------------------------------------------------------------------------- Test description System description Reference Organism Strain/cell type ---------------------------------------------------------------------------------------- Chromosome damage (contd.) breaks, human anion cells Poirier & Papadopoulo gaps, exchanges, ( in vitro ) (1982) complexes sister chromatide human lymphocytes Star (1980a)

Participants who completed VESPER-1 were eligible to enroll in an exploratory open-label extension that evaluated higher weekly dosing (1.6 mg, 2.4 mg) and less frequent dosing (every other week and monthly)

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