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As shown in Figure 2 , following stimulation of GLP-1R by exenatide on microglia, the cAMP/PKA/p38/CREB signal transduction pathway is activated, promoting the expression of IL-10

Using his RIA he was able to show that in the fasting state glucagon gets released in addition to insulin to raise plasma glucose

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HR 1.19, 95% CI 0.91.58), but not for the other DPP-4 inhibitors as in the TECOS study for sitagliptin (HR 1.00, 95% CI 0.831.20) or the CARMELINA study for linagliptin (HR 0.90, 95% CI 0.741.08) (57, 62, 64, 65, 68)

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