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As epigenetic modifiers, STLs can modulate the p53 signaling pathway, suppress oncogenic signaling pathways, reduce the activation of major hepatocarcinogenesis-related oncogenes, and inhibit the epithelial-mesenchymal transition [110,111,112]

Prolonged sun exposure, combined with environmental stressors such as pollution and a fast-paced lifestyle, can increase oxidative stress 1 in the body and stimulate excess melanin production

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TFBUT = Tear Film Break-up Time