This antibody seems currently to be the only antibody that measures the GLP-1R expression correctly and specifically 25,26,27
Slow titration doesn't just feel betterit actually leads to better adherence and outcomes
You should specifically discuss Wegovy with your GP if you: Are currently taking any thyroid medication , including levothyroxine, liothyronine, or antithyroid drugs Have a history of thyroid disease or thyroid nodules Have experienced thyroid function changes in the past with weight fluctuations Are planning pregnancy (semaglutide should be discontinued at least 2 months before planned conception, and effective contraception should be used while on treatment) During Wegovy treatment , contact your GP promptly if you experience: Symptoms suggesting thyroid dysfunction : unexplained fatigue, cold intolerance, hair loss, palpitations, anxiety, or tremor Neck symptoms : swelling, lumps, difficulty swallowing, or persistent hoarseness Significant changes in how you feel on your thyroid medication, suggesting your dose may need adjustment Difficulty tolerating Wegovy side effects, particularly if they interfere with taking your thyroid medication properly Seek urgent medical attention if you develop: Severe, persistent abdominal pain (with or without vomiting), which could indicate pancreatitis Jaundice (yellowing of skin/eyes) or severe right upper abdominal pain, which might suggest gallbladder problems Your GP may arrange thyroid function blood tests if you develop symptoms or as part of routine monitoring
Implications for treatment
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The presence of multiple hgp genes may allow for selective expression of the Hgp with greatest affinity for the predominant host haemoglobin-haptoglobin phenotype, or alternatively as a strategy to evade the host immune response mounted against a particular Hgp-expressing population (Langlois and Delanghe, 1996)
