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In order to be taken up by the liver it has to be degraded to amino acids. [I also wonder- since glutamate is elevated in metabolic disease, and a residue in the GSH tripeptide, might it be that providing glycine or serine to support synthesis could be preferred over glutathione

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However, these studies have not been extended to a structure-activity relationship that allows prediction of the spin-trapping affinity of nitrones for specific radical species