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Existing reviews have further highlighted that pharmacokinetic and safety characterization in humans remains incomplete, complicating clinical counseling regarding timing of discontinuation, perioperative risk stratification, and postoperative resumption (Rahman et al
A successful example of ADCs using a non-cleavable linker is the humanized anti-HER2 antibody-maytansine conjugate trastuzumab emtansine (T-DM1, or Kadcyla ) (LoRusso et al., 2011
Worse still, these symptoms didnt exist in isolation
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