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Co-depletion of EXO1 did not alleviate the fork degradation phenotype of PDS5B deficient cells (Supplementary Fig

The principle has been applied by optimizing the concentrations of substrates and cofactors of both GR and GP activities in order to obtain that only GP is the limiting enzyme activity of our RBC enzyme complex system

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Moreover, it is worth mentioning that drug interaction and potent inhibitors of cytochrome P450 (CYP) 3A4 inhibitors (atorvastatin is metabolized by CYP3A4) can significantly increase statin concentrations (Hirota et al., 2020), and clinical research on atorvastatin tends to apply high dose (Pedersen et al., 2005) since high-dose atorvastatin is superior in preventing peripheral arterial disease (Stoekenbroek et al., 2015)