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However, these synthetic DPP-IV inhibitors have been reported to have a number of adverse effects, such as gastrointestinal adverse reactions, allergic reactions, skin-related side effects, and musculoskeletal disorders

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In some cases, a low level of inflammation exists for several weeks before a diagnosis is made

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The combination is in fact better with leucine as it improves the composite score of mTOR protein level which reflects muscle mass and strength