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IGFBP-2 is highly expressed in the blood of lung tumors and patients with lung cancer and high levels of IGFBP-2 are associated with poor survival and metastasis in patients with lung cancer
Furthermore, the use of ABPP to profile proteomic states has largely been restricted to lysates 8,10 , where protein interactions and compartmentalization are disrupted, potentially obscuring PTM-regulated binding events or generating artifacts due to probing of non-native conditions
Every step in this chain is vulnerable to age-related decline
PMC6271067 Seiwerth, S., et al
Neuroradiology 49, 715720
Novel isoforms of NADPH oxidase in vascular physiology and pathophysiology
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