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Modafinil (Provigil), a wakefulness- and cognition-promoting drug used for the treatment of conditions such as narcolepsy, has also been used to treat ADHD and has shown promise in clinical trials on both children and adults with ADHD

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This happens largely because appetite returns to previous levels, and the metabolic improvements gained during treatment are no longer present

In support of this, shGDH1 cells exhibited reduced expression of mitochondrial electron transport chain (ETC) subunits and lower respiratory capacity, which could be greatly recovered by exogenous -KG (Supplementary Fig

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