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There are two main types of injury mechanisms: primary and secondary

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Besides their autocrine/paracrine and structural roles, brain pericyte also engage in crosstalk with brain microvascular endothelial cells, promoted in part via gap junctions between the cells

Hepatic necrosis is preventable in overdose with timely administration of N-acetyl-cysteine (NAC) which restores glutathione reserves, allowing for safe excretion of these hepatotoxic metabolites