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The involvement of the NLRP3 inflammasome pathway has also been implicated, with pharmacological inhibition of TLR4/NF-B/NLRP3 signaling attenuating neuroinflammation and improving tinnitus behavior in noise-exposed mice (Luo et al., 2024)

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Another study showed that active tablets containing calcium butyrate (500 mg/tablet), zinc gluconate (zinc 5 mg/tablet), and vitamin D3 (500 IU/tablet) improved liver steatosis and several NAFLD-related parameters [146]

Women using oral contraceptives should consider using a non-oral method or additional contraception for 4 weeks after initiating tirzepatide and for 4 weeks after each dose increase

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Step 9: Monthly follow-ups