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doi: 10.1086/424881 135 McComseyGALibuttiDEO'RiordanMSheltonJMStorerNGanzJet al

Regulation of aged humoral immune defense against pneumococcal bacteria by IgM memory B cell

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In their study, human-derived monocytes were treated with either PMA, pharmacologic G6PD inhibitor 6-AN, G6PD-silencing siRNA, siRNA + hyperglycemia, or hyperglycemia alone and then inspected for changes in monocyte polarization without an immunogenic stimulus