doi:10.1016/j.molmet.2018.09.009 40
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A preclinical study finds that the widely used metabolic drug tirzepatide suppresses alcohol intake and relapse-like behaviors in rodents while altering brain reward signaling, highlighting a potential new direction for treating alcohol use disorder
The numbers are estimates, as they can fluctuate, but the structure is what's important
Mice were placed onto a cage hopper and infused with semaglutide, GLP-1MK-801 or vehicle (isotonic saline) over 60 s at a total infusion volume of 2 l through a Hamilton syringe mounted onto an automated syringe pump (Harvard Apparatus) and a 33-gauge internal cannula (PlasticsOne, C315IS-4/SPC, 2.5 mm)
"Xenobiotic metabolism: a look from the past to the future"