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Association of glucagon-like peptide-1 receptor agonist use with risk of gallbladder and biliary diseases: a systematic review and meta-analysis of randomized clinical trials

410 Mechanism-based combination strategies may enhance the efficacy of autophagy-targeted therapies

Pooled 2020-2026 data (12 studies, n=892) report mild erythema (4.2%), pruritus (2.1%), no systemic copper overload (serum levels unchanged)

When activated, beta-3-AR triggers Gs protein coupling, adenylyl cyclase activation, cAMP production, protein kinase A phosphorylation, and hormone-sensitive lipase translocation to lipid droplets for triglyceride hydrolysis

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