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Andreeff M , Marini FC, Westin S, Coleman R, Thall P, Al Jahdami V, Qazilbash M, Rezvani K, Timmons M, Heese L, Wang RY, Champlin RE, Shpall E, Olson A

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The systemic administration of large molecules can lead to off-target effects and potentially induce adverse reactions in tissues that are not the intended target [14]

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Metabolism of amino-acids: the synthesis of glutamine from glutamic acid and ammonia, and the enzymic hydrolysis of glutamine in animal tissues