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Vitamin B (pyridoxine), when chronically taken in gram quantities, is known to cause a sensory neuropathy, numbness and tingling in the extremities, but the amount of B in this formula (2 mg per mL) is far below such neurotoxic levels

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The 60/40 approach places 60 percent of the dose in the morning (fasted) and 40 percent in the evening (before dinner or before bed)

Serious but rare complications include hypokalaemia and anaphylaxis, which requires immediate emergency care

However, your doctor may recommend different dosing depending on your individual needs